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KMID : 0381319790180010001
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Korean Journal of Occupational Health
1979 Volume.18 No. 1 p.1 ~ p.10
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Provocative Chelation by D-Penicillanmine Applied to Diagnosis of Lead Poisoning
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Abstract
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For the purpose of obtaining reference materials which may be applied to diagnosis of lead poisoning and absorption by D-penicillamine chelation technique, 4-hour fractionated urinary lead excretion was determined under various dosage schedule on 90 lead workers who were either heavily exposed to or intoxicated with lead. The observation groups consisted of nine groups of ten persons and each group was administered 200 ㎎, 300 ㎎ or 400 ㎎ of oral D-penicillamine, either once daily, twice daily at 12-hour intervals or thrice daily at 6-hour intervals.
The results were as follows:
1. 24-hour urinary lead excretion increased by 2.3 to 6.0 times after daily oral D-penicillamine of 200~1,200 ㎎ as compared with initial excretion.
2. 4-hour fractionated urinary lead excretion reached plateau usually within 0-4 hours after each dose of D-penicillamine, though frequently plateau was observed in 4-8 hour period with single doses of D-PCA.
3. 4-hour fractionated urinary lead excretion showed close association with initial lead excretion only when three doses of 400 ㎎ D-penicillamine were administered at 6-hour intervals. No association was noted with initial blood lead, urinary coproporphyrin or δ-aminolevulinic acid levels.
4. Determination of lead in third period 4-hour fractionated urine after 2doses of 400 ㎎ D-penicillamine given at 6-hour intervals seems most helpful for diagnosis of lead poisoning and absorption.
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